Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color or feel of a mole. Most melanomas have a black or black-blue area. Melanoma may also appear as a new mole. It may be black, abnormal or "ugly looking."
Thinking of "ABCD" can help you remember what to watch for:
Melanoma can be cured if it is diagnosed and treated early. If melanoma is not removed in its early stages, cancer cells may grow downward from the skin surface and invade healthy tissue. If it spreads to other parts of the body it can be difficult to control.
Who gets melanoma?Anyone can get melanoma, but some people are more likely to get it. If you answer "yes" to any of the questions below, you may be more at risk. Talk with your doctor about your risk factors.
What does a melanoma look like?
A melanoma might look like a mole or a bump or growth on your skin. Melanomas often do not look bad at first.

The ABCDE rule can help you remember what to look for when you're checking any moles on your skin:
A for asymmetry : A mole that, when divided in half, doesn't look the same on both sides
B for border : A mole with edges that are blurry or jagged
C for color : Changes in the color of a mole, including darkening, spread of color, loss of color, or the appearance of multiple colors such as blue, red, white, pink, purple or gray
D for diameter : A mole larger than 1/4 inch in diameter (about the size of a pencil eraser)
E for elevation : A mole that is raised above the skin and has a rough surface
You should also watch for the following skin changes:
Also be aware that moles can grow in hidden areas of your body, such as between toes, on your scalp or under a nail. If you notice a mole that has changed, or if you have a new mole that doesn't look like your other moles, visit your doctor right away.
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Find out more at Minimal Residual Disease in Melanoma