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Dietary Implications for the Development of Acne: A Shifting Paradigm - Part 5

A report by Loren Cordain, Ph.D., Professor, Department of Health and Exercise Science, Colorado State University

The Epidermal Growth Factor Receptor

BTC from ingested bovine milk may contribute to the pathogenesis of acne by its ability to increase keratinocyte cell proliferation and to decrease keratinocyte apoptosis. Further, BTC up-regulates its own receptor, thereby causing additional signaling through the EGF receptor pathway. In support of the notion that increased flux through the EGF receptor pathway by exogenous BTC from milk may promote acne is the observation that EGF receptor blocking
pharmaceuticals cause non-comedonal acne in most patients who are administered these drugs.

Loren Cordain, MD, is a Professor in the Department of Health and Exercise Science at Colorado State University in Fort Collins, Colorado. His research emphasis over the past 10 years has focused upon the evolutionary and anthropological basis for diet, health and well being in modern humans. Dr Cordain’s scientific publications have examined the nutritional characteristics of worldwide huntergatherer diets as well as the nutrient composition of wild plant and animal foods consumed by foraging humans. More recently his work has focused upon the adverse health effects of the high dietary glycemic load that is ubiquitous in the typical western diet. A number of his recent papers have proposed a common endocrine link between dietary induced hyperinsulinemia and dermal manifestations such as acne, ancanthosis nigricans and cutaneous papillomas. Dr Cordain is the author of more than 100 peerreviewed publications, including a series of three recent papers outlining the central role diet plays in causing acne. He is the recent recipient of the Scholarly Excellence award at Colorado State University for his contributions into understanding optimal human nutrition. He has lectured extensively on the evolutionary aspects of human nutrition world wide, including presentations on how diet plays a key role in the pathogenesis of acne at the annual conferences of the Society for Investigative Dermatology (SID) and the European Society of Dermatology and Venerology (EADV). He has written a popular book, The Dietary Cure for Acne, summarizing his research findings.

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